Complex_037

Description : retromer complex

Functional Grouping : Cytoskeleton/vesicle structure and dynamics

Subcellular localisation : Endosome

Comments : Vps5 contains a PX domain (277-390) and a C-terminalcoiled coil region that mediates its interaction with Vps17.Vps17 contains a PX domain (105-223) and a C-terminalcoiled coil region that mediates its interaction with Vps5.The PX domains of the sorting nexins (Vps5 and Vps17) maycorrespond to the so-called retromer assembly domain.

Affinity purifications :

EM rank : 3

Bioinformatics
Component	Length	Status	Pfam Doms	COGs	PDB match	Modellable	PFAM Ints	SCOP Ints
VPS29	282	known	Metallophos	x	Good	All	no	no
VPS26	379	known	Vps26	x	-	-	no	no
VPS35	944	missing	Vps35	x	-	-	no	no
VPS5	675	missing	PX	x	Good	Domain	yes	no
VPS17	551	known	PX	x	Good	Domain	yes	no

Potential Cross-talk
Confidence 1(low)->7(high)	Complex1	Complex2	Comp1	Comp2	Exp	PFAM1	PFAM2	Template	Zscore	PID1	E-val1	Begin1	End1	PID2	E-val2	Begin2	End2
1	037	135	VPS29	PPH3	no	Metallophos	Metallophos	x	x	x	x	x	x	x	x	x	x

Patrick Aloy