Complex_125

Description : cohesin complex

Functional Grouping : Chromosome dynamics

Subcellular localisation : Mitotic chromosomes

Comments : The architecture of cohesin based on the crystal structure of bacterial SMC proteins and EM has been predicted [11983169].

Affinity purifications :

EM rank : 3

Bioinformatics
Component	Length	Status	Pfam Doms	COGs	PDB match	Modellable	PFAM Ints	SCOP Ints
SCC1	566	known	Rad21_Rec8 Rad21_Rec8_N	x	-	-	no	no
SMC1	1225	known	HOOK Myosin_tail SMC_C SMC_N	x	Good	Domain	yes	yes
SCC3	1150	missing	STAG	x	-	-	no	no
SMC3	1230	known	Myosin_tail SMC_C SMC_N	x	Good	Domain	yes	yes

Potential Cross-talk
Confidence 1(low)->7(high)	Complex1	Complex2	Comp1	Comp2	Exp	PFAM1	PFAM2	Template	Zscore	PID1	E-val1	Begin1	End1	PID2	E-val2	Begin2	End2
5	125	328	SMC1	SMC2	yes	SMC_C	SMC_N	x	x	x	x	x	x	x	x	x	x
5	125	328	SMC3	SMC2	yes	SMC_N	SMC_C	x	x	x	x	x	x	x	x	x	x
5	125	328	SMC3	SMC4	yes	SMC_C	SMC_N	x	x	x	x	x	x	x	x	x	x
4	125	328	SMC1	SMC4	no	SMC_C	SMC_N	x	x	x	x	x	x	x	x	x	x

Patrick Aloy