Complex_257

Description : CCT complex

Functional Grouping : Chaperonin complexes

Subcellular localisation : ? (cytoskeleton/cytoplasm)

Comments : A dimer of archaeal CCT-like thermosome subunits has been crystallised {1A6D} and a model of two octameric rings presented [9546398]. The order of the eukaryotic subunits in the ring has been determined [12354605]. An EM of this complex is available [12456645]. Plp2 is a distant homologue of phosducin and Vid27 of transducin beta 1, which have been cocrystallised {1B9X}.

Affinity purifications :

EM rank : 1

Bioinformatics
Component	Length	Status	Pfam Doms	COGs	PDB match	Modellable	PFAM Ints	SCOP Ints
CCT4	528	missing	cpn60_TCP1	x	Good	All	yes	yes
CCT6	546	missing	cpn60_TCP1	x	Good	All	yes	yes
CCT1	559	missing	cpn60_TCP1	x	Good	All	yes	yes
CCT2	527	missing	cpn60_TCP1	x	Good	All	yes	yes
CCT8	568	missing	cpn60_TCP1	x	Good	All	yes	yes
CCT3	534	missing	cpn60_TCP1	x	Good	All	yes	yes
CCT7	550	known	cpn60_TCP1	x	Good	All	yes	yes
CCT5	551	missing	cpn60_TCP1	x	Good	All	yes	yes
VID27	782	new		x	Good	Domain	no	yes
PLP2	286	new	Phosducin	x	Good	Domain	no	yes

Potential Cross-talk
Confidence 1(low)->7(high)	Complex1	Complex2	Comp1	Comp2	Exp	PFAM1	PFAM2	Template	Zscore	PID1	E-val1	Begin1	End1	PID2	E-val2	Begin2	End2
1	257	108	PLP2	CPS50	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	147	PLP2	RET1	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	147	PLP2	SEC27	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	153	PLP2	ARC40	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	159	PLP2	TAF90	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	162	PLP2	PFS2	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	170	PLP2	ELP2	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	235	PLP2	SEH1	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	235	PLP2	SEC13	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	249	PLP2	CAC3	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	249	PLP2	CAC2	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	108	PLP2	CPS30	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	251	PLP2	SKI8	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	258	PLP2	VPS15	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	108	PLP2	CPS35	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	109	PLP2	VPS41	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	119	PLP2	GLE2	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	136	PLP2	TAF90	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	136	PLP2	SPT8	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	137	PLP2	UME1	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x
1	257	138	PLP2	TIF34	no	Phosducin	WD40	x	x	x	x	x	x	x	x	x	x

Patrick Aloy